L-Pyroglutamic Acid
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L-Pyroglutamic Acid

L-Pyroglutamic Acid (also known as PCA, 5-oxoproline, pidolic acid, or pyroglutamate for its basic form) is a ubiquitous but little studied natural amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam.It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate, or enzymatically converted by glutaminyl cyclases. This is one of several forms of blocked N-termini which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.

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L-Pyroglutamic acid CAS:98-79-3


L-Pyroglutamic acid CAS:98-79-3 basic information:

Synonyms:5-OXO-L-PROLINE;5-oxoproline;5-OXO-2-PYRROLIDINECARBOXYLIC ACID;L-GLUTIMINIC ACID;L-GLUTAMIC ACID LACTAM;(-)-L-PYROGLUTAMIC ACID;L-PYROGLUTAMIC ACID;L-2-PYRROLIDONE-5-CARBOXYLIC ACID

MF:C5H7NO3

MW:129.11

EINECS:202-700-3

Mol File:98-79-3.mol

Appearance and Properties: White Fine Crystal

Density: 1.38 g / cm3

Melting Point: 160-163°C (lit.)

Boiling Point: 453.1ºC at 760 mmHg

Flash Point: 227.8ºC


L-Pyroglutamic acid CAS:98-79-3 Introduction

Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid, or pyroglutamate for its basic form) is a ubiquitous but little studied natural amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam.

It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase.

Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate, or enzymatically converted by glutaminyl cyclases. This is one of several forms of blocked N-termini which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.


L-Pyroglutamic acid CAS:98-79-3 Specification:

Item

Specifications

Results

Appearance

Off-White crystalline powder

Conforms

Specific rotation(a)D20 (C=2,H20)

-10.5°to -11.8°

-11.6°

Melting point (°C)

158°C to 161°C

159.5°C

Chloride (C1)

NMT 0.02%

0.01%

Ammonium (NH4)

NMT 0.02%

<0.02%

Sulfate (SO4)

NMT 0.05%

0.005%

Heavy metals (Pb)

NMT 10ppm

10ppm

Iron(Fe)

NMT 20ppm

8ppm

Arsenic (As2O3)

NMT 1ppm

<1ppm

Loss on drying

NMT  0.50%

0.39%

Residue on ignition

NMT  0.2%

0.07%

Assay

98.0-101.0%

99.3%

 

L-Pyroglutamic acid CAS:98-79-3 Function

For food, medicine, cosmetics and other industries; organic synthesis intermediates, food additives

1.L-Pyroglutamic Acid is cardio protection; prevention of atherosclerosis

2.L-Pyroglutamic Acid is cancer prevention

3.L-Pyroglutamic Acid is prevention of tooth decay and gum disease

4.L-Pyroglutamic Acid is kidney function improvement

5.L-Pyroglutamic Acid anti-platelet aggregation to prevent blood clotting

6.L-Pyroglutamic Acid is liver protection

7.L-Pyroglutamic Acid is protection and restoration of immune system

8.L-Pyroglutamic Acid is inhibition of infectious pathogens


L-Pyroglutamic acid CAS:98-79-3 Application

1. It can be used in nail cosmetics. ,

2, L-pyroglutamic acid can also be synthesized with other organic compounds

Derivatives have special effects on surface activity, transparency and brightness. ,

3. It can be used as surfactant, detergent, chemical reagent and organic intermediate for the resolution of racemic amine. 




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