China H&Z® Diosmin is also called Alvenor. It is a kind of drug for the treatment of hemorrhoid symptoms related to acute episodes, can also be used in the treatment of symptoms associated with venous lymphatic insufficiency (leg heavy, pain, morning acid swells discomfort).Diosmin hesperidin is a plant chemical that is classified as a "bioflavonoid". It is found primarily in citrus fruits. People use it asmedicine.Hesperidin alone, or in combination with other citrus bioflavonoids (diosmin, for example), is most often used for bloodvessel conditions such as hemorrhoids,varicose veins, and poor circulation (venous stasis). It is also used to treat lymphedema, a condition involving fluid retention that can be a complication of breast cancer surgery.
China Diosmin Factory
Diosmin CAS NO:520-27-4
H&Z® Diosmin is a naturally occurring flavonoid glycoside that can be isolated from various plant sources or derived from the flavonoid
hesperidin. Diosmin is considered to be a vascular-protecting agent used to treat chronic venous
insufficiency,hemorrhoids,lymphedema, and varicose veins. As a flavonoid, diosmin also exhibits anti-inflammatory, free-radical
scavenging, and antimutagenic properties.
H&Z® Diosmin has been used for more than 30 years as a phlebotonic and vascularprotecting agent,and has recently begun to be investigated for other therapeutic purposes, including cancer, premenstrual syndrome, colitis, and diabetes.
Function of Diosmin
1. Treatment of venous lymphatic insufficiency associated symptoms (heavy legs, pain, discomfort, soreness early morning) - the
treatment of acute hemorrhoid attack on a variety of symptoms.
2. With vitamin P-like effects, can reduce vascular fragility and abnormal permeability, but also for the control of the adjuvant
treatment of hypertension and arteriosclerosis, for the treatment of capillary fragility was better than rutin, hesperidin and
stronger, and has low toxicity characteristics.
3. Of the vein system to play its active role in reduce venous distensibility and venous stasis zone.
1.Diosmin prolongs the vasoconstrictor effect of norepinephrine on the vein wall, increasing venous tone, and therefore reducing venous capacitance, distensibility, and stasis.
2.Diosmin increases the venous return and reduces venous hyperpressure present in patients suffering from CVI.
3.Diosmin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, and by increasing the total number of functional lymphatic capillaries.
4.Diosmin with hesperidine decreases the diameter of lymphatic capillaries and the intralymphatic pressure.
5.At the microcirculation level, diosmin reduces capillary hyperpermeability and increases capillary resistance by protecting the microcirculation from damaging processes.
6.Diosmin reduces the expression of endothelial adhesion molecules,and inhibits the adhesion, migration, and activation of leukocytes at the capillary level.Diosmin leads to a reduction in the release of inflammatory mediators, principally oxygen free radicals and prostaglandins.