Tranexamic Acid

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China Tranexamic Acid Factory

Tranexamic acid CAS:1197-18-8

Tranexamic acid Chemical Properties
MF:C8H15NO2
MW:157.21
EINECS:214-818-2
Melting point:>300 °C(lit.)
Boiling point:281.88°c (rough estimate)
Density:1.0806 (rough estimate)
Refractive index:1.4186 (estimate)
Solubility:Freely soluble in water and in glacial acetic acid, practically insoluble in acetone and in ethanol (96 per cent).
Pka:Pka 4.3 (uncertain);10.6 (uncertain)
Water Solubility:1g/6ml
Merck:14,9569
BRN:2207452

Tranexamic acid CAS:1197-18-8 Introduction:
H&Z® Tranexamic acid is a synthetic derivative of the amino acid lysine. It is used to treat or prevent excessive blood loss during surgery and in various other medical conditions. It is anantifibrinolytic that competitively inhibits the activation of plasminogen to plasmin, by binding to specific sites of both plasminogen and plasmin, a molecule responsible for the degradation of fibrin, a protein that forms the framework of blood clots. Tranexamic acid has roughly eight times theantifibrinolytic activity of an older analogue, ε-aminocaproic acid. 
Tranexamic acid has been found to decrease the risk of death in people who have significant bleeding due to trauma. However, it may actually increase the risk of death due to bleeding if administered more than 3 hours after the injury

Tranexamic acid CAS:1197-18-8 Specification:

Items	Standards	Results
Physical Analysis
Description	White Crystalline Powder	Complies
Assay	98%	98.62%
Mesh Size	100 % pass 80 mesh	Complies
Ash	≤5.0%	2.85%
Loss on Drying	≤5.0%	2.65%
Chemical Analysis
Heavy Metal	≤10.0 mg/kg	Complies
Pb	≤2.0 mg/kg	Complies
As	≤1.0 mg/kg	Complies
Hg	≤0.1mg/kg	Complies
Microbiological Analysis
Residue of Pesticide	Negative	Negative
Total Plate Count	≤1000cfu/g	Complies
Yeast&Mold	≤100cfu/g	Complies
E.coil	Negative	Negative
Salmonella	Negative	Negative

Tranexamic acid CAS:1197-18-8 Function:
1Post-partum bleeding
A large, international study was conducted on the use of tranexamic acid after childbirth to prevent hemorrhaging. The trial found that tranexamic acid significantly reduced the risk of death from hemorrhaging after childbirth.
2.Mouthwash for oral procedures
An antifibrinolytic mouthwash can be used for controlling bleeding after an oral procedure such as a tooth extraction. The tranexamic acid mouthwash is used prior to the procedure and immediately afterwards to prevent and reduce bleeding.
3.Melasma
Topically applied tranexamic acid has been shown to significantly improve the appearance of melasma.

Tranexamic acid CAS:1197-18-8 Application:
1. Trauma: Tranexamic Acid Powder has been found to decrease the risk of death in people who have significant bleeding due to trauma. 
2. Heart surgery: Tranexamic Acid is commonly used in cardiac surgery, both with and without cardiopulmonary bypass. 
3. Orthopedic surgery: Tranexamic Acid Powder is used in orthopedic surgery to reduce bloodloss. 
4. Menstrual bleeding:Used as firstline nonhormonal treatment of dysfunctional uterine bleeding, and heavy bleeding associated with uterine fibroids. 
5. Dentistry: Tranexamic Acid Powder is used in dentistry in the form of a 5% mouth rinse after extractions or surgery in patients with prolonged bleeding time, e.g. from acquired or inherited disorders.
6.In hemophilia: Tranexamic Acid Powder is also useful in the treatment of bleeding as a second line treatment after factor VIII in patients (e.g. tooth extraction).
7.Whitening effect: Clinical studies for years have proved that tranexamic acid can dilute spot effectively and rapidly, which helps to demonstrate a perfect white and bright skin. The spot-removing effect of tranexamic acid is about 50 times over Vitamin C, and 10 times over AHA. The concentration limit of usage is 2%-3%, and in cosmetics the amount is around 0.5%.    
8.H&Z® Tranexamic Acid Powder is used for Comestics,freckle whitening an so on.