D-Glucurone of H&Z® factory is a naturally occurring substance that is an important structural component of nearly all connective tissues.Glucuronolactone is also found in many plant gums.
Glucuronolactone is hydrolyzed in the body to glucuronic acid, which may be oxidized to glucaric acid, or isomerized to another hexuronic acid, so there is no reasonable toxicity mechanism.